A similar reduction in TGF-β-induced 4 × SBE-Luc reporter activity was found by Smyca knockdown in HCC cell line Malaru (Additional file 1: Fig. S3E), which expressed a higher level of Smyca than another HCC cell line NTU-BL (Additional file 1: Fig. S2A). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.