The previous study has shown that the impact of the IL-7δ5 variant through the activation of Akt has a critical role in cell proliferation, apoptosis, angiogenesis, and metastasis [17], but in our study, there is no correlation between IL-7 serum level and lymph node metastasis, LVI, or PNI, and neither with tumor size has been noticed. This evidence concerns the gene IL7 and metastatic malignant neoplasm in the lymph nodes.