The previous study has shown that the impact of the IL-7δ5 variant through the activation of Akt has a critical role in cell proliferation, apoptosis, angiogenesis, and metastasis [17], but in our study, there is no correlation between IL-7 serum level and lymph node metastasis, LVI, or PNI, and neither with tumor size has been noticed. Here, AKT1 is linked to neoplasm.