Based on the scopolamine-induced cognitive impairment, we observed the behavioral phenotype of AD model mice and found that ASF effectively repair the cognitive impairment induced by scopolamine, as evidenced by improving memory and learning ability, reducing the pathological injury of hippocampal neurons, increasing the level of Ach, decreasing the activity of AchE. The gene discussed is FGFR3; the disease is Alzheimer disease.