LV-NC, LV-METTL3-shRNA, LV-NC + LV-HHLA2OE, and LV-METTL3-shRNA + LV-HHLA2OE subgroups (1 × 107 in 150 μL PBS) based on 786-O cell line were used to establish subcutaneous transplantation tumor model in nude mice (4 ~ 5 weeks old). Here, METTL3 is linked to neoplasm.