And in our present study, first, we found that METTL3 expression level was significantly and positively associated with HHLA2 expression, and the combination of METTL3 and HHLA2 expression in human ccRCC tissues could be used as an important predictor for poor prognosis, suggesting the potential role of METTL3 in the regulation of HHLA2. This evidence concerns the gene METTL3 and nonpapillary renal cell carcinoma.