Besides, we also evaluated the migration ability of the ccRCC cell lines after depletion of METTL3 and found that at the time point of 24 h, the relative wound closure rate of LV-METTL3-shRNA (P < 0.05 in 786-O and P < 0.01 in ACHN cells, Fig. 2G and H) was significantly increased compared with LV-NC, suggesting that depletion of METTL3 significantly reduced the migration ability of ccRCC cell lines. This evidence concerns the gene METTL3 and nonpapillary renal cell carcinoma.