Wang et al. have demonstrated that most of the m6A RNA methylation regulators could be found abnormally expressed in ccRCC tissues, playing important roles in the initiation and progression of ccRCC, especially two powerful independent prognostic m6A RNA methylation regulators, METTL14 and METTL3 [14]. The gene discussed is METTL3; the disease is nonpapillary renal cell carcinoma.