In addition, our experiment may require further study in the leukemia mouse model, and further study on the of the role and mechanism of SEMA4D/PlexinB1 in the bone marrow microenvironment such as bone marrow stromal cells and mesenchymal stem cells, so as to better understand the role of SEMA4D/PlexinB1 in acute myeloid leukemia. This evidence concerns the gene PLXNB1 and leukemia.