In addition, our experiment may require further study in the leukemia mouse model, and further study on the of the role and mechanism of SEMA4D/PlexinB1 in the bone marrow microenvironment such as bone marrow stromal cells and mesenchymal stem cells, so as to better understand the role of SEMA4D/PlexinB1 in acute myeloid leukemia. The gene discussed is SEMA4D; the disease is acute myeloid leukemia.