Intracellular PN inhibition and OP recovery could also improve the markedly abnormal membrane potential, cell volume, and ion homeostasis, which was supported by the data showing that inhibitors of HCN, L-VGCC, and TRPV4 channels and recovery agents of Na+/K+ ATPase has less effect on the improvement of OP and pulmonary edema than inhibition of PNs, TRPC6, and SUR1-TRPM4. Here, TRPC6 is linked to pulmonary edema.