The category of core binding factor (CBF) acute myeloid leukaemias (AMLs) includes AML with inv(16)(p13.1q22) and AML with t(8;21) (q22;q22,1), which translates into CBFβ/MYH11 and RUNX1/RUNX1T1 fusion genes, respectively [16]. The gene discussed is CBFB; the disease is acute myeloid leukemia.