According to research conducted by Fukata and coworkers, the TLR4 was upregulated in colon cancer samples from patients with chronic ulcerative colitis and animal model of colitis-associated cancer (CAC) and contributed to the colon carcinogenesis by activating the EGFR (epidermal growth factor receptor) signaling [71]. Here, EGFR is linked to malignant colon neoplasm.