We discovered that SVOP, FDFT1, and TRIM67 were significantly higher in COAD tissues than in colon normal tissue (Fig. 10), and also, NRIP2 was barely expressed in COAD tissues and colon normal tissue in the HPA dataset, while NRIP2 was reported to be up-regulated in CCICs from both cell lines and primary colorectal cancer tissues [19]. The gene discussed is SVOP; the disease is colorectal cancer.