To better understand the potential influence of RT on TIGIT expression in tumor-infiltrating lymphocytes (TILs), we performed a post-hoc exploratory analysis that compared variations in TIGIT expression in CD8 + T cells, CD4 + T cells and NK cells (Fig. S1) between pre- and post-treatment tumor samples in each group using immunofluorescence staining. Here, CD4 is linked to neoplasm.