Interestingly, we observed a strong downregulation of STING gene expression in both LUAD (Pval = 1.626e-07) and LUSC (Pval = 3.637e-12) (Supplementary Fig. S11F, G), suggesting that STING downregulation in SCLC and LCNEC types is even stronger in comparison to normal lung tissues. The gene discussed is STING1; the disease is large cell neuroendocrine carcinoma.