IFNB1 and large cell neuroendocrine carcinoma: As STING expression was reduced in SCLC subtype as interferon response, we performed a correlation analysis of STING expression and “Response to Interferon Beta” gene set enrichment for each cancer type showing a positive but slight correlation between STING and “Response to Interferon Beta” GO process in LUSC and neuroendocrine cancer types (SCLC and LCNEC) but not in LUAD (Fig. 6e).