Furthermore, through a survey of Cancer Cell Line Encyclopaedia (CCLE) data [41], we observed that small-cell lung cancer cell lines DMS114, H889, and, to a lower extent, H209, show a high methylation level of STING gene that strongly affects gene expression, that is lower than STING expression in HeLa cells (Supplementary Fig. S11I). This evidence concerns the gene STING1 and small cell lung carcinoma.