Furthermore, through a survey of Cancer Cell Line Encyclopaedia (CCLE) data [41], we observed that small-cell lung cancer cell lines DMS114, H889, and, to a lower extent, H209, show a high methylation level of STING gene that strongly affects gene expression, that is lower than STING expression in HeLa cells (Supplementary Fig. S11I). Here, STING1 is linked to cancer.