Interestingly, in three different SCLC cell lines (H82, H526 and H1048) wherein STING and cGAS genes are expressed, PARP inhibitors were shown to increase the cellular levels of IFN-B gene mRNA along with activated pathway factors such as pSTING_S366 and cGAS [44]. The gene discussed is CGAS; the disease is small cell lung carcinoma.