TOP1 and small cell lung carcinoma: As methylation of STING gene can result in a reduced expression in SCLC cells (see below), we treated DMS114 cells with 5’-azacytidine (a demethylating agent, [35]) to increase STING expression (Supplementary Fig. S9A on the right), however, Top1 poisons were still not able to activate immune genes (Supplementary Fig. S9A).