As shown in Fig. 5E, the percentages of apoptotic cells were 11.46% and 12.08% in siPD-L1#1 and siPD-L1#2 group, respectively, compared with 7.69% in siNC group (P < 0.01), suggesting that the downregulation of PD-L1 expression could promote cell apoptosis in AML leukemic cell line. The gene discussed is CD274; the disease is acute myeloid leukemia.