Elevated AEG-1 expression leads to enhanced phenotypic characteristics of malignant invasion in tumour cells, including an increased proliferative capacity, invasion of surrounding tissues, migration, induction of neovascularization, and enhancement of tumour resistance4, while inhibition of AEG-1 by siRNA not only reduces the metastasis and invasion of human glioma cells5 but also reduces the expression of the MDR1 gene, thereby decreasing the resistance of tumours to chemotherapeutic drugs6. The gene discussed is MTDH; the disease is central nervous system cancer.