Specifically, Wnt family genes FZD4, FZD5, CTNNB1 and downstream targets CCDN1, VEGFA, axin2 were upregulated in end-stage of Pulmonary Arterial Hypertension condition, which is a life-threatening disease associated with increase pulmonary pressures, subsequently followed by development of right-sided heart failure73. This evidence concerns the gene FZD4 and pulmonary arterial hypertension.