This is rather remarkable, but it appears that restoring function to specific brain regions can exert broad benefits in MeCP2 mutant mice: stimulating the motor circuit in a forced exercise paradigm not only improves motor coordination but reduces anxiety and extends the lifespan of male Mecp2-null mice27, and restoring activity in area CA1 improves social behavior in a mouse model of MeCP2 duplication syndrome42. The gene discussed is MECP2; the disease is Anxiety.