Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA),212 low-density lipoprotein receptor-related protein 1 (LRP1),213 lipoprotein lipase (LPL),214 SREBF1/2,215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-α, and TGF-β1)216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders. Here, CCL2 is linked to metabolic disease.