Thus, chemerin may increase insulin sensitivity in adipose tissue.141,142 Adipocytes also produce apelin that is increased in insulin resistant individuals143 and morbidly obese subjects with T2DM.144 However, apelin enhances glucose uptake and Akt phosphorylation through AMPK pathway to improve glucose homeostasis and insulin sensitivity,145 apelin deficient mice are insulin resistant and have decreased skeletal muscle Akt phosphorylation.146 The precise role of anti-inflammatory adipokine in regulating IR require further investigation. This evidence concerns the gene APLN and type 2 diabetes mellitus.