In fact, through screening choline analogues Wang et al. found that 3, 3-dimethyl-1-butanol (DMB, an analogue of choline) had an obvious inhibitory effect on CutC, thus reduced the production of TMA; and they showed that DMB decreased the level of TMAO in animals.16 As TMA is metabolized into TMAO in human liver by FMO3, the transformation from TMA to TMAO has become a possible target against atherosclerosis as well.17 The present study showed that dhBBR, instead of BBR itself, might be the one that inhibits the activity of either CutC or FMO. The gene discussed is CUTC; the disease is atherosclerosis.