KEAP1 and ischemic stroke: Also, damaged blood-brain barrier induces the iron to be transferred into neuronal cells, which further enhances ferroptosis.212 From another perspective, ferroptosis is also closely associated with oxidative stress, in which signaling pathways such as calcium-related signals, ATF4 and Keap1-Nrf2 signaling pathways play a role.213 Despite being less frequently discussed, ferroptosis may also be greatly involved in the pathogenesis of ischemic stroke,with a variety of signaling pathways potentially participating in.