Mitophagy is essential for maintaining cellular homeostasis and serves as a protective strategy in various central nervous system diseases.132 Signaling pathways, such as PTEN induced kinase 1 (PINK1)/Parkin, Bcl2-interacting protein 3 (Bnip3), BNIP3-like, and FUN14 domain containing 1 pathways, are reportedly involved in mitophagy during ischemia–reperfusion. Here, PINK1 is linked to central nervous system disorder.