IL1B and ischemic stroke: Majorly observed in ischemic penumbra, pyroptosis potentially induces pro-inflammatory pathways in ischemic stroke.207 During the process of pyroptosis, cells get swollen and cellular organelles are released to induce inflammation, in which caspase-1 is activated and form inflammasomes.208 All these contribute to pyroptotic cell death and secretion of inflammatory factors, such as IL-1β and IL-18.208,209