NFKB1 and brain ischemia: On the one hand, deletion of NRF2 results in increased inflammation, as well as high levels of NF-κB; on the other hand, the elevated expression of NRF2 inhibits NF-κB-regulated pro-inflammatory and immune responses.119 This show the neuroprotective effects of NRF2 against NF-kB-induced inflammatory responses in cerebral ischemia.