EP300 and Alzheimer disease: Recently, considering the complexity of aging and neurodegeneration, Nativio et al. integrated transcriptomic, proteomic, and epigenomic analyses of postmortem human brains (lateral temporal robe) to identify epigenetic alterations associated with AD compared with older and younger controls.174 First, previous RNA-seq data were analyzed, presenting the upregulation of the chromatin genes such as CBP, p300, and TRRAP (a subunit of the SAGA–ATAC complex) in the temporal lobe of AD brains as mentioned earlier.