Several HMTs were elevated in patients with AD (Fig. 5).162,184–186 H3K4me3 methyltransferases such as MLL3 (KMT2C), MLL4 (KMT2D), SETD1A, and SETD1B were significantly elevated in patients with AD, compared to control subjects. This evidence concerns the gene KMT2C and Alzheimer disease.