Dysregulation of histone acetylation is related to memory decline and AD (Fig. 5).162 Histone acetyltransferase activity of CBP (KAT3A) is required for neurogenesis and memory consolidation in rodents.163–167 Several studies suggested that an increase in CBP expression is considered a valid therapeutic approach for AD. The gene discussed is CREBBP; the disease is Alzheimer disease.