Interestingly, we previously found that such CD127–CD103+CD45RO+ ILCs are particularly enriched in MMR-deficient colorectal cancers, and have characteristics of intraepithelial ILC1-like cells.31 In contrast to the exceptional high levels of cytotoxic enzymes present in this population in colorectal cancers, we found that only up to 10% of the CD45RO+ ILC1-like cells expressed granzyme B/perforin in PDAC tissues. Here, PRF1 is linked to colorectal cancer.