ANXA1 and neoplasm: Despite the lower bacteria burden in non-tumor cells in the TME, we also conducted an analysis of the correlation of immune or stromal subgroups with bacterial burden via deconvolution of transcriptomic information from each non-tumor cell group based on previous single-cell RNA sequencing results.12–15 We discovered a correlation between the abundance of CD4 T cells with the bacterial burden, more specifically a subgroup of conventional (non-regulatory αβ) CD4 T cells with ANXA1 gene expression14 (figure 4A, online supplemental figure S6).