CD8+ T cells themselves were reported to promote the recruitment of activated CD8+ T cells into tumors by recruiting various DCs via CCL3, CCL4 and XCL1.43 CCL4 from tumor cells may be essential in triggering the early phase of DC recruitment, while CCL4 from tumor-infiltrating CD8+ cells may further amplify the accumulation of DCs and T cells later as a positive feedback system for antitumor T cell responses. This evidence concerns the gene XCL1 and neoplasm.