SCD and melanoma: Since it was reported that SCD1 expression and activity were bidirectionally regulated by the Wnt/β-catenin signaling16 17 and that activation of the Wnt/β-catenin signaling inhibited CCL4 production via activation of ATF3 in human melanoma cells,18 we evaluated whether SCD1 regulates CCL4 production via β-catenin-ATF3 axis in these tumor cell lines.