Transcriptome analysis of 57 advanced colon cancer samples revealed that one of the non-T cell inflamed subtypes (group 4) had low expression of CD8a, IFNG and GZMB with high expression of SCD1 and CTNNB1(β-catenin) and its downstream molecules including VEGFA and TCF12. Here, TCF12 is linked to malignant colon neoplasm.