MUFA (palmitoleic acid) synthesized by SCD1 is ligated to Wnt protein, leading to its activation of β-catenin signaling.27–29 Oleic acid produced by SCD1 and its downstream metabolites, polyunsaturated 18-carbon fatty acids, stabilize β-catenin in cancer cells by preventing its proteasomal degradation.25 These observations suggest that SCD1 inhibition suppresses Wnt/β-catenin signaling in cancer cells through multiple mechanisms. The gene discussed is SCD; the disease is cancer.