SCD and melanoma: Oleic acid was previously reported to stabilize β-catenin levels in cancer cells by preventing its degradation by proteasomes.25 Knockdown of β-catenin gene in these tumor cells or overexpression of mutant β-catenin gene in human melanoma cell line 938-mel expressing low β-catenin gene19 also regulated SCD1 expression in a negative or positive manner in the tumor cell lines (online supplemental figure 4A, B), indicating that SCD1 and β-catenin regulate their expression in a bidirectional manner.