ATF3 and neoplasm: Expression of the chemokine CCL4, which is important for recruiting DCs into tumors,18 was significantly increased by SCD1 inhibition (figure 2D), accompanied by the decreased expression of activating transcription factor 3 (ATF3) (figure 2E), a transcription factor that inhibits CCL4 expression.24 These results suggest that SCD1 inhibition enhances the production of CCL4 in tumor tissues via ATF3 inhibition, which in turn promotes the induction and effector function of tumor antigen specific CD8+ T cells through the accumulation and maturation of DCs in tumors.