We treated IL-9 knockout mice during AOM/DSS procedures with hyperIL-6, a designer fusion protein consisting of the soluble IL-6 receptor and IL-6.34 Strikingly, IL-9-deficient mice given hyperIL-6 showed an induction and development of colorectal tumours comparable to wild-type mice [Figure 5F]. Here, IL6 is linked to colorectal neoplasm.