Previous studies with cancer patients also have shown that the Ezrin, Radixin, and Moesin complex interferes in the expression of membrane receptors, opioid metabolization, and pain modulation, with its activated form being related to greater resistance to the effect of opioids and greater presence of central sensitization, while the inactive form would be related to the opposite effect, similar to what the authors have observed in dyschezia.22 The gene discussed is MSN; the disease is Constipation.