Since these proteins play a role in cell attachment and invasion, and in order to investigate their role in the pathogenesis of endometriosis, the aim of the present study is to evaluate the expression of Ezrin and Phosphorylated Ezrin in endometriotic lesions and their relation with the menstrual cycle phase, stage of endometriosis, histological classification, and clinical symptoms. This evidence concerns the gene EZR and endometriosis.