Some studies have indicated that polymorphisms in genes related to innate and adaptive immune response [toll-like receptors (TLRs), human leukocyte antigen (HLA) class I and II, and cytokines/chemokines] and in genes involved in viral binding and entry into host cells (angiotensin converting enzyme-2 –ACE2, and transmembrane serine protease–TMPRSS) are associated with COVID-19 development and/or severity [6–8, 12]. This evidence concerns the gene ACE2 and COVID-19.