RUNX2 and acute lymphoblastic leukemia: Whereas overexpression prematurely gives rise to IL-2Rβ+ stage 3 progenitors on day 7 of culture and increases IL-2Rβ levels in ALL-SIL cells, silencing does not generate a significant difference, which can be attributed to residual RUNX2 levels that might be sufficient to control IL-2Rβ expression.