TF and neoplasm: Using DS% to rank the tumor samples from low to high, we next assessed all the Hallmarks (Supplementary Fig. S3C), alongside the subset of Hallmarks and TFs that were found to be significantly associated with stroma/epithelium in the LCM and FACS cohorts (Fig. 4C and D), revealing a strikingly clear pattern that again indicates how widely the stromal components of a tumor can confound the interpretation of transcriptional signatures and TF activity scores in the bulk tumor setting.