KRAS and neoplasm: This was particularly evident for the signatures we have identified to be confounded by stromal content in our LCM, FACS, and bulk tumor datasets, exemplified by positive correlation of EPITHELIAL MESENCHYMAL TRANSITION (Spearman rho = 0.96, P = 1.7e-08), KRAS SIGNALING UP (Spearman rho = 0.87, P = 7.9e-07), alongside negative correlation with the MYC TARGETS V2 (Spearman rho = -0.63, P = 0.00037) signature (Fig. 5H).