SURF1 and Leigh syndrome: In the context of LS, iPSCs have been successfully generated from patients with mutations in mitochondrially encoded ATP synthase membrane subunit 6 (MT-ATP6) (Galera-Monge et al., 2016; Grace et al., 2019; Lorenz et al., 2017; Ma et al., 2015), mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 (MT-ND3) subunit (Hattori et al., 2016) and the nuclear-encoded gene surfeit locus protein 1 (SURF1) (Inak et al., 2021).