We analyzed the pleiotropic effect of the common SNP rs1061234 of HBG1, and the results showed that this SNP significantly increased the incidence of 7 phenotypes, including venous thromboembolism, coronary atherosclerosis, and deep vein thrombosis (DVT) of the lower extremities; however, no significant decrease in the incidence of other phenotypes was detected, demonstrating that the pleiotropic effect of HBG1 is relatively weak. This evidence concerns the gene HBG1 and deep vein thrombosis.