rs78378222 is a common SNP of TP53, and it significantly increases (β > 0, P < 0.05) the incidence of 17 phenotypes, including gastroduodenal ulcers, malignant neoplasms of the prostate, and meniscus derangement, and significantly reduces (β < 0, P < 0.05) the incidence of 3 phenotypes, including disorders of the lens and actinic keratosis. Here, TP53 is linked to actinic keratosis.