In a case report published by Farag et al, another 52-year-old patient with a germline variant in KIT exon 11, p.Trp557Arg, with multiple GISTs was treated with imatinib and had a rapid tumor regression with subsequent disease stability for 7 years, followed by resection of residual disease.22 Two of the 3 patient’s children undergoing predictive testing were found to carry the familial variant. This evidence concerns the gene KIT and neoplasm.