An upregulation of immune checkpoint inhibitors such as PD‐1 and PD‐L1 has been reported in microsatellite instability high‐deficient mismatch repair (MSI‐HdMMR) CRC tumors seen in early‐stage cancers which allow immune evasion by TILs [262, 263]. This evidence concerns the gene CD274 and colorectal carcinoma.