Furthermore, IL‐33 is a reported influential proangiogenic factor in CRC [236, 237] and promotes angiogenesis and vascular leakage by stimulating endothelial nitric oxide triggered by the ST2/TNF receptor associated factor 6 (TRAF6)‐Akt‐endothelial nitric oxide synthase (eNOS) signaling pathway [236]. This evidence concerns the gene IL33 and colorectal carcinoma.