Furthermore, cytokines such as GM‐CSF, macrophage colony‐stimulating factor (M‐CSF), IL‐6, IL‐10, IL‐1β, PGE2, and TGF‐β, whether secreted or produced by tumor‐derived exosomal vesicles, enter the bone marrow or circulation, and generate MDSCs [194]. The gene discussed is IL6; the disease is neoplasm.