Moreover, many signaling cascades are involved in TGF‐β signaling in cancer for promoting tumor progression [186, 187, 188], including a novel signaling cascade of TGF‐β‐metastasis associated 1 (MTA1)‐SOX4‐enhancer of Zeste 2 polycomb repressive complex 2 subunit (EZH2) that drives EMT in CRC. Here, TGFB1 is linked to neoplasm.