An upregulation of immune checkpoint inhibitors such as PD‐1 and PD‐L1 has been reported in microsatellite instability high‐deficient mismatch repair (MSI‐HdMMR) CRC tumors seen in early‐stage cancers which allow immune evasion by TILs [262, 263]. The gene discussed is PDCD1; the disease is colorectal carcinoma.