Furthermore, cytokines such as GM‐CSF, macrophage colony‐stimulating factor (M‐CSF), IL‐6, IL‐10, IL‐1β, PGE2, and TGF‐β, whether secreted or produced by tumor‐derived exosomal vesicles, enter the bone marrow or circulation, and generate MDSCs [194]. This evidence concerns the gene TGFB1 and neoplasm.