Expression of cadherin 1 (CDH1), the gene encoding E‐cadherin, in CRC is suppressed by various transcription factors: snail family transcriptional repressor 2 (SNAI2), zinc finger E‐box‐binding homeobox 1 (ZEB1), transcripton factor activating enhancer‐binding protein 4 (TFAP4), twist‐related protein 1 (TWIST1), transcription factor 4 (TCF4), SRY‐box transcription factor 2 (SOX2), octamer‐binding transcription factor 4 (OCT4), Nanog, high mobility group AT‐hook 1 (HMGA1), and fos‐related antigen 1 (FRA1) [157, 158, 159, 160, 161, 162, 163, 164, 165, 166]. Here, SOX2 is linked to colorectal carcinoma.