NFKB1 and neoplasm: Preclinical studies have shown the involvement of TNF‐receptor 2 (TNFR2) signaling in the development of CAC, suggesting that TNFR2 activation is an important mechanism for epithelial barrier loss, NF‐κB‐dependent tumor cell survival, and proinflammatory cytokine release [250, 251, 252].