At the same time, a dysregulated immune response caused by decreased PLT is likely also be responsible for the increased disease severity of COVID-19, as a higher ratio of lymphopenia and increased levels of neutrophils, serum CRP, and IL-6 were observed in the patients with COVID-19 and thrombocytopenia observed at the early infection according to our study. Here, CRP is linked to Thrombocytopenia.