Six genes involved in Waardenburg syndrome include PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2) [4, 8–18]. The gene discussed is EDN3; the disease is Waardenburg syndrome.