However, according to data obtained from the TCGA, CGGA, and GEO databases, glioma patients with a low expression of GRB10 were associated with a longer survival period than patients with a high expression of GRB10. Furthermore, RT-qPCR analysis of tumor samples obtained from 68 patients with gliomas revealed that higher histological grades were associated with poorer overall survival (OS). The gene discussed is GRB10; the disease is neoplasm.