PPI network analyses showed that the hub genes (CCR2, PTPRC, CXCR2, MNDA, S100A9, NCF2, S100A12, and S100A8) were upregulated in both NAFLD and AF datasets and may play crucial roles in the pathogenesis of NAFLD and AF. The gene discussed is S100A9; the disease is metabolic dysfunction-associated steatotic liver disease.