PPI network analyses showed that the hub genes (CCR2, PTPRC, CXCR2, MNDA, S100A9, NCF2, S100A12, and S100A8) were upregulated in both NAFLD and AF datasets and may play crucial roles in the pathogenesis of NAFLD and AF. This evidence concerns the gene CXCR2 and atrial fibrillation.