For FSH analysis, the opposite result was observed, serum FSH level was positively related to the severity of depression (Q4:Q1 OR 1.62, 95%CI 1.00–2.62; Q3:Q1 OR 1.60, 95%CI 1.15–2.23; Q2:Q1 OR 1.44, 95%CI 1.06–1.97). This evidence concerns the gene BRD2 and major depressive disorder.