Another protein differentially expressed in all the 100 iterations and the top hit of the main analysis in the stimulated samples (log2 fold change = 5.35), was Grb2-related adapter protein encoded by GRAP. Of note, Grb2-related adapter protein 2 encoded by the MS susceptibility gene GRAP2 was expressed at higher levels in CD4+ T cells from MS patients as compared to HCs in our previously published proteomic analyses [26]. The gene discussed is GRAP2; the disease is myeloid sarcoma.