LINC00511 and malignant colon neoplasm: Gain and loss-of-functional experiments demonstrated that LINC00511 increased sphere development, stem factor production, and contributed to the preservation of breast cancer CSC characteristics, implying that LINC00511 played a role in tumor cell differentiation [29]. CSCs were previously identified from breast cancer, lung malignancy, colon cancer, malignant melanoma, and glioblastoma [26].