THP-1 cells used in our study are KMT2A-MLLT3pos cells, and CDK6 was demonstrated to be important for differentiation in KMT2A-rearranged AML cells, but genetic down-regulation of CDK6 in study by Placke et al.39 induced mild G0/G1 arrest associated with differentiation, while we observed an arrest of THP-1 cells in S and G2/M-phase. Here, CDK6 is linked to acute myeloid leukemia.