It is possible that the CCA cells treated with 0% CH-CM might express a higher level of IL-6 and pJAK2 than those treated with 75% CH-CM therefore, the addition of IL-6 only increased the pJAK2 level in CCA cells treated with 75% CH-CM but not in CCA cells treated with 0% CH-CM that already express a high level of IL-6 and pJAK2. Here, IL6 is linked to cholangiocarcinoma.