A BIM (BCL-2-interacting mediator of cell death) plasmid encapsulated in a folate “lipoplex” was developed to target the tumor microenvironment in lung cancer30 and an anti-mouse FRβ monoclonal antibody conjugated to Pseudomonas exotoxin A depleted TAMs and reduced tumor growth a C6 rat glioma model33. The gene discussed is FOLR2; the disease is central nervous system cancer.