After controlling by recipient age, pre-transplant coronary heart disease, pre-transplant renal replacement therapy and donation after circulatory death (CDC), there was a significant association between the presence of the minor T allele of TLR3 (rs3775291) SNP in homozygosis (TT genotype) and the occurrence of BKPyV viremia (adjusted hazard ratio [HR]: 2.16; 95% confidence interval [CI]: 1.08–4.30; P value = 0.029). The gene discussed is TLR3; the disease is coronary artery disorder.