ACP3 and neoplasm: Similar to our above findings with CDX3379-MMAE or ACPP-MMAE conjugate monotherapy in syngeneic murine tumor models (Fig. 2), MMAE monotherapy lacked significant anti-tumor efficacy in three well described syngeneic murine models (LL/2, B16, and MC38) when delivered to tumors using the ACPP scaffold52 (Fig. 3e, Supplementary Fig. 9d).