Importantly, CDX3379-MMAE + IR significantly increased CD8 tumor cell infiltration when compared to vehicle control, CDX3379 antibody alone, CDX3379-MMAE alone, IR alone or CDX3379 + IR-treated tumors (Fig. 4b) providing evidence that MMAE drug warhead and not the carrier antibody-stimulated immune infiltration of the irradiated tumor immune microenvironment. This evidence concerns the gene CD8A and neoplasm.