Overexpression of MTHFD2 is reported in several malignancies and associated with tumor invasion, metastasis and poor prognosis, for instance, the increased expression of MTHFD2 is correlated with tumor growth in renal cell carcinoma, hepatocellular carcinoma, and lung cancer [18–20]. The gene discussed is MTHFD2; the disease is hereditary clear cell renal cell carcinoma.