The relationship between STC2 expression in cancer tissues and the prognostic outcomes is controversial as STC2 functions as an oncogene in some type of cancers including colon, lung, and hepatocellular carcinomas, but a tumor suppressor in other types of cancer, as evidenced by its suppression of breast cancer cell migration and invasion [14, 27–30]. The gene discussed is STC2; the disease is hepatocellular carcinoma.