PKM and lung cancer: To investigate the roles of PKM2 and TRIB2 in regulating lung cancer cell growth in vivo, lentiviral vectors were then constructed as a previous report [28] to stably express PKM2, shPKM2, TRIB2, shTRIB2, or controls to further investigate the effect of PKM2 or TRIB2 on cancer cell proliferation in xenografts.