BCL2L11 and endometrial cancer: Therefore, it was hypothesized that SNORD89 might play an oncogenic role in endometrial cancer by regulating Bim. SNORD89 performs 2′-O-methylation modification mainly by binding to RNA-methylated proteins such as Fibrillarin (Fbl) or competitive endogenous RNA by binding to proteins such as Argonaute (AGO2).