By extracting tumor tissue proteins and Western blotting experiments, the Bcl-2 protein were increased, and the levels of Bim proteins were decreased in tumor tissues overexpressing SNORD89. SNORD89 can be further verified by influencing Bim and its mediated Bcl-2/Bax signaling axis to participate in the occurrence and development of endometrial cancer. The gene discussed is BCL2; the disease is neoplasm.