Polymorphisms in certain genes predispose individuals to develop more severe liver disease in NAFLD, e.g. patatin‐like phospholipase domain‐containing protein 3 (PNPLA3); trans‐membrane 6 super family 2 (TM6SF2); glucokinase regulator (GCKR); membrane‐bound O‐acyltransferase domain containing 7 (MBOAT7).40 The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.