Considering the influence of NAFLD‐susceptibility genes (i.e., PNPLA3 rs738409 c.444 C > G p.I148M and TM6SF2 rs58542926 C > T E167K) that also decrease VLDL secretion (i.e., an example of horizontal pleiotrophy), analyses were repeated after exclusion of these NAFLD susceptibility genes that also impair VLDL secretion. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.