MARCHF5 and persistent truncus arteriosus: Representative M-mode echocardiograms on control-TAC and MITOL-cKO-TAC mice, two weeks after TAC surgery, are shown in Figure 4G. MITOL-cKO mice displayed significantly more serious cardiac damage to TAC surgery than control mice, as observed by impairment of systolic function (Figure S4B, Figure 4H).