From a mechanistic perspective, the modulated functioning of tumor promoter (such as cyclin E, c-Myc, cyclin D1, c-Jun, etc.)or suppressor (e.g. RASSF1) proteins, which are bona fide substrates of SCF assembly, appears to be puppeteer of Skp1 perpetration in either case (Shiba-Ishii et al., 2019; Tian et al., 2020; Wu et al., 2021). Here, SKP1 is linked to neoplasm.