On one hand, separate lines of inquiry have documented that Skp1 overactivation or overexpression promotes cancer stemness, cancer initiation, and progression, and correlates with poorer patient outcome as well (Liu et al., 2015; Shiba-Ishii et al., 2019; Tian et al., 2020; Wu et al., 2021; Zhu et al., 2021). The gene discussed is SKP1; the disease is cancer.