Knockdown experiments have previously suggested that survival of some cancer cell lines (including A549) may depend on Skp1 (Liu et al., 2015; Tian et al., 2020; Zhu et al., 2021), whereas its pharmacological inhibition with 6-OAP has been demonstrated to reduce the viability of A549 cells (Liu et al., 2015). The gene discussed is SKP1; the disease is cancer.